Prolactin
Product Specification:
Prolactin is an acidic, single chain polypeptide secreted by the cells in the anterior pituitary gland. Prolactin is very similar to hGH in structure. Prolactin may be found in several forms. Monomeric prolactin accounts for 40 - 80% of the prolactin present in the pituitary gland. Big Prolactin, a dimer of the prolactin molecule accounts for 10%. Prolactin is also found in glycosylated, phosphorylated, and sulfated forms. These variations in the prolactin molecule exhibit differences in immunological and bioactivity. The cells producing prolactin (lactotrophs) are higher in the female population than the male and increase during pregnancy. The major function of prolactin is the initiation and maintenance of lactation in women. Prolactin is available as standard grade (50%) and as High purity (95%).
General Information:
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Molecular Weight: 26,000 Daltons
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Source: Human pituitary extract
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IU/mg Standard grade 20 IU/mg
-
IU/mg High purity 28 IU/mg
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Form: lyophilized powder
Storage - 20 degrees C
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Stability: 5 years from date of manufacture
Method of Analysis:
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Purity is determined by SDS-Page.
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Acceptable level Standard grade: 50%
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Acceptable level High purity: 95%
Activity is determined by one of the following methods:
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Method DPC Immulite 1000
Reference Preparation WHO 3rd IS 84/500 -
Method ACS 180
Reference Preparation WHO 2nd IRP (80/552)
Contaminants Tested:
|
Contaminant |
Method |
Acceptable level; Standard Grade |
Acceptable level; High Purity |
|
hGH |
DPC Immulite 1000 |
Less than 1.5% |
Less than 0.2% |
|
LH |
ACS 180 |
Less than 1% |
Less than 0.1% |
|
TSH |
ACS 180 |
N/A |
Less than 0.1% |
|
FSH |
ACS 180 |
N/A |
Less than 0.1% |
