Thyroid Stimulating Hormone (TSH)
Product Specification:
TSH is a glycoprotein having two subunits. The alpha subunit is similar to those of FSH, HCG, and LH. The beta subunit is different from the other hormones and confers its biochemical specificity. TSH is secreted by the basophilic cells of the anterior pituitary. TSH is responsible for regulating thyroid function. TSH is available as whole molecule standard (50%) and High purity (95%) grades, or as alpha and beta subunits.
General Information:
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Molecular Weight: 28,500 Daltons alpha- 13,500 beta-15,000
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Source: Human pituitary extract
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IU/mg Standard grade 4.0 IU/mg
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IU/mg High purity 8.5 IU/mg
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Form: lyophilized powder
Storage - 20 degrees C
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Stability: 5 years from date of manufacture
Method of Analysis:
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Purity is determined by SDS-Page.
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Acceptable level Standard grade: 50%
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Acceptable level High purity: 95%
Activity is determined by one of the following methods:
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Method Abbott IMX
Reference Preparation WHO 2nd IRP (80/558) -
Method ACS 180
Reference Preparation WHO 2nd IRP (80/558)
Contaminants Tested:
|
Contaminant |
Method |
Acceptable level; Standard Grade |
Acceptable level; High Purity |
|
FSH |
ACS 180 |
Less than 0.5% |
Less than 0.2% |
|
LH |
ACS 180 |
Less than 2% |
Less than 0.2% |
|
GH |
DPC Immulite 1000 |
N/A |
Less than 0.2% |
|
PRL |
ACS 180 |
N/A |
Less than 0.1% |
